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If concomitant use is critical, take into account rising the SUBUTEX dosage right until stable drug consequences are reached. Monitor for signs of opioid withdrawal.Buprenorphine has become uncovered to be a CYP2D6 and CYP3A4 inhibitor and its big metabolite, norbuprenorphine has become located to be a reasonable CYP2D6 inhibitor in in vitro scient